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New antibody: Cyclin D1 clone CCND1/3370R

Rabbit monoclonal antibody

Recognizes a protein of 36kDa, identified as Cyclin D1, one of the key cell cycle regulators, is a putative protooncogene overexpressed in 2 wide varieties of human neoplasms. This antibody neutralizes the activity of Cyclin D1 in vivo. About 60% og mantle cell lymphomas (MCL) contain at (11;14)(q13;32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas from CLL/SLL and follicular lymphomas. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.


Catalog No.ContentsVolume
ILM3370-C01Cyclin D10,1 ml concentrate
ILM3370-C05Cyclin D10,5 ml concentrate
ILM3370-C1Cyclin D11,0 ml concentrate

Intended use: For Research Use Only

Reactivity: Human

Clone: CCND1/3370R

Species of origin: Rabbit

Isotype: IgG

Gene ID: 595

SwissProt: P24385

Unigene: 523852 & 667996

Control Tissue: Human mantle cell lymphoma, breast or bladder carcinomas

Staining: Nuclear   

Immunogen: A synthetic peptide corresponding to residues within aa 270-295 of Cyclin D1

Presentation: Bioreactor Concentrate within 0.05% Azide

Application and suggested dilutions:

Pre-treatment: Heat induced epitope retrieval in 10 mM citrate buffer, pH6.0 for 20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections.

  • Immunohistochemical staining of formalin-fixed, paraffin embedded tissue section (dilution 1:50-1:100)

The optimal dilution for a specific application should be determined by the investigator.

Note: Dilution of the antibody in 10% normal goat serum followed by a Goat anti-Rabbit secondary antibody-based detection is recommended.

Storage & Stability: Store at 2-8 °C. Do not use after expiration date printed on the vial.


  1. Baldin V, et al. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Development, 1993, 7(5):812-21
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