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New antibody: Bcl-6 clone MX042

Mouse Monoclonal Antibody


The Bcl-6 protein (B-cell CLL/lymphoma 6, zinc finger protein 51) is a nuclear zinc finger transcription factor with an N-terminal POZ domain. Bcl-6 functions as a transcriptional repressor and is necessary for germinal centre formation. The Bcl-6 protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 response of B-cells. Mutations of the Bcl-6 gene have been found in normal germinal centre B-cells, and even though it is not clear what role they play in lymphomagenesis, it appears that they may disrupt its negative autoregulation and in this manner promote lymphoma growth.


Catalog No.ContentsVolume
ILM0746-C01Bcl-60,1 ml concentrate
ILM0746-C05Bcl-60,5 ml concentrate
ILM0746-C1Bcl-61,0 ml concentrate

Intended use: For Research Use Only

Reactivity: Human, others not known

Clone: MX042

Species of origin: Mouse

Isotype: IgG

Control Tissue: Tonsil

Staining: membranous  

Presentation: 1ml Bcl-6 tissue culture supernatant contains 15mM Azide

Application and suggested dilutions:
Pre-treatment: Heat induced epitope retrieval in 10 mM citrate buffer pH6.0 for  20 minutes is required for IHC staining on formalin-fixed, paraffin embedded tissue sections.

  • Immunohistochemical staining of formalin-fixed, paraffin embedded tissue section (dilution up to 1:100)

    The optimal dilution for a specific application should be determined by the investigator.

Note: Dilution of the antibody in 10% normal goat serum followed by a Goat anti-Mouse secondary antibody-based detection is recommended.

Storage & Stability: Store at 2-8 °C. Do not use after expiration date printed on the vial.


  1. Dwivedi A, Mehta A, Solanki P. Evaluation of immunohistochemical subtypes in diffuse large B-cell lymphoma and its impact on survival. Indian J Pathol Microbiol. 2015 Oct-Dec; 58(4):453-8
  2. Huang C, Melnick A. Mechanisms of action of BCL6 during germinal center B cell development. Sci China Life Sci. 2015 Dec;58(12):1226-32

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